PTH -Intact (Parathyroid Hormone)
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Parathyroid Hormone (PTH) is an 84-amino acid peptide hormone secreted by the parathyroid glands
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🧪 What is PTH – Intact?
Parathyroid Hormone (PTH) is an 84-amino acid peptide hormone secreted by the parathyroid glands. The Intact PTH test measures the biologically active, full-length hormone circulating in the blood, which plays a crucial role in calcium and phosphorus homeostasis.
❓ Why is the Test Done?
To:
- Diagnose and differentiate causes of hypercalcemia and hypocalcemia
- Evaluate parathyroid gland function
- Diagnose primary, secondary, and tertiary hyperparathyroidism
- Monitor patients with chronic kidney disease (CKD) or renal osteodystrophy
- Assess bone metabolism disorders
📊 Normal Range
Intact PTH Level | Reference Range |
|---|---|
Adults | 10 – 65 pg/mL |
Reference ranges may vary slightly depending on the assay and laboratory.
📈 Interpretation of Results
PTH Level | Clinical Implications |
|---|---|
Elevated PTH with hypercalcemia | Primary hyperparathyroidism (parathyroid adenoma or hyperplasia) |
Elevated PTH with hypocalcemia | Secondary hyperparathyroidism (e.g., CKD, vitamin D deficiency) |
Low or suppressed PTH with hypercalcemia | Malignancy, vitamin D intoxication, granulomatous diseases |
Low PTH with hypocalcemia | Hypoparathyroidism (surgical, autoimmune, congenital) |
🧠 Associated Conditions
System/Organ | Conditions |
|---|---|
Parathyroid glands | Hyperparathyroidism, hypoparathyroidism |
Kidneys | CKD-related secondary hyperparathyroidism |
Bones | Osteitis fibrosa cystica, renal osteodystrophy |
Endocrine system | Calcium-phosphorus metabolism disorders |
🔄 Related / Follow-Up Tests
- Serum calcium (total and ionized)
- Serum phosphorus
- Vitamin D (25-OH and 1,25-(OH)2D)
- Alkaline phosphatase (ALP)
- Renal function tests (creatinine, eGFR)
- 24-hour urinary calcium
✅ Fasting Required?
Test | Fasting Required |
|---|---|
PTH – Intact | ❌ No |
📝 Summary Table
Parameter | Details |
|---|---|
What | Measures biologically active parathyroid hormone levels |
Why | Diagnose parathyroid and calcium-phosphorus disorders |
Normal Range | 10–65 pg/mL |
Elevated Levels | Primary or secondary hyperparathyroidism |
Low Levels | Hypoparathyroidism |
Associated Conditions | Hyper/hypoparathyroidism, CKD, bone metabolism disorders |
Follow-up Tests | Calcium, phosphorus, vitamin D, ALP, renal function |
Fasting Required | ❌ No |
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