Reticulocyte Count
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Percentage of immature red blood cells; increased in active erythropoiesis or anemia recovery.
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🧪 What is Reticulocyte Count?
The Reticulocyte Count measures the percentage or absolute number of reticulocytes—immature red blood cells—in the blood. It reflects the bone marrow’s response to anemia by showing how actively new red blood cells are being produced.
❓ Why is the Test Done?
To:
- Evaluate bone marrow function and erythropoietic activity
- Differentiate between types of anemia (production vs. destruction/loss)
- Monitor response to anemia treatment
- Diagnose hemolytic anemia or blood loss
- Assess recovery after bone marrow suppression or transplantation
📊 Normal Range
Reticulocyte Percentage | Normal Range | ||
|---|---|---|---|
Adults | 0.5% – 2.5% of RBCs | ||
Absolute Reticulocyte Count | Normal Range | ||
Adults | 25,000 – 75,000 cells/µL | ||
📈 Interpretation of Results
Result | Clinical Significance |
|---|---|
Increased Reticulocytes | Response to anemia due to blood loss or hemolysis |
Decreased Reticulocytes | Bone marrow failure, aplastic anemia, nutrient deficiency |
Normal Reticulocytes | Anemia due to decreased production without marrow response |
🧠 Associated Conditions
Condition | Details |
|---|---|
Hemolytic anemia | Increased reticulocytes due to RBC destruction |
Acute blood loss | Elevated reticulocytes as marrow compensates |
Bone marrow suppression | Decreased reticulocytes |
Nutritional anemia (B12/folate) | Low reticulocyte count due to impaired RBC production |
🔄 Related / Follow-Up Tests
- Complete Blood Count (CBC)
- Peripheral Blood Smear
- Serum Iron, Vitamin B12, Folate
- Bone marrow biopsy (if marrow pathology suspected)
- Reticulocyte Production Index (RPI) – corrected for anemia severity
✅ Fasting Required?
Test | Fasting Required |
|---|---|
Reticulocyte Count | ❌ No |
📝 Summary Table
Parameter | Details |
|---|---|
What | Measures immature red blood cells in blood |
Why | Assess bone marrow response to anemia |
Normal Range | 0.5% – 2.5% or 25,000–75,000 cells/µL |
High Count | Hemolysis, blood loss, marrow response |
Low Count | Bone marrow failure, nutrient deficiency |
Associated Conditions | Hemolytic anemia, marrow suppression, acute bleeding |
Follow-up Tests | CBC, blood smear, iron/B12/folate, bone marrow biopsy |
Fasting Required | ❌ No |
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