Rubella - IgG

Bacterial/ Viral

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No Fasting Required

Details

Measures the presence and level of Immunoglobulin G (IgG) antibodies against the Rubella virus in the blood

₹199₹660

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Rubella - IgG Antibody Test

Why is it done?
- Detects IgG antibodies to rubella virus, indicating past infection or immunity from vaccination
- Assesses immunity status before pregnancy or for vaccination purposes
- Confirms past rubella infection or vaccination history in individuals with uncertain immunization records
- Part of routine preconception screening for women of childbearing age
- Performed as part of prenatal screening to prevent congenital rubella syndrome (CRS)
- Ordered for healthcare workers and other high-risk populations requiring documented immunity
Normal Range
- Negative/Non-Immune: < 0.8-1.0 IU/mL or < 8-10 AU/mL (units vary by laboratory) Indicates no immunity from past infection or vaccination
- Positive/Immune: > 1.0-1.1 IU/mL or > 10-11 AU/mL Indicates immunity from vaccination or past infection; patient is protected
- Borderline/Equivocal: 0.8-1.0 IU/mL or 8-10 AU/mL May require repeat testing or additional IgM testing; borderline immunity
- Note: Reference ranges vary significantly among laboratories; always consult laboratory-specific normal values
Interpretation
- Positive IgG Result: Patient has immunity to rubella; either previously infected or successfully vaccinated; protected against future infection; low risk of congenital rubella syndrome if pregnant; does not require vaccination
- Negative IgG Result: Patient lacks immunity to rubella; at risk for infection; vulnerable to congenital rubella syndrome if infection occurs during pregnancy; requires MMR (measles, mumps, rubella) vaccination; vaccination should not occur during pregnancy
- Recent Infection Consideration: IgG alone cannot differentiate between past and recent infection; if recent infection suspected (clinical symptoms present), IgM testing is required; acute infection shows IgM positive and IgG negative or low; IgG levels increase during convalescence
- Factors Affecting Results: Time since vaccination (immunity wanes in some individuals); immunocompromised status (may show false negative); passive immunity from maternal antibodies (in infants); laboratory methodology variations; individual immune response differences; presence of interfering substances or hemolysis
- Clinical Significance: Essential for public health surveillance; helps identify non-immune populations; critical for preventing outbreaks in susceptible groups; high antibody titers may indicate recent infection or booster vaccination
Associated Organs
- Primary System - Immune System: Measures immune response to rubella antigen; involves lymphocytes and antibody production
- Respiratory System Involvement: Rubella virus infects via respiratory droplets; causes upper respiratory symptoms and rash; can progress to systemic infection
- Reproductive System Concerns: Critical for prenatal screening; negative results in pregnant women require immediate counseling; first trimester infection causes congenital rubella syndrome
- Associated Conditions from Active Infection: Congenital rubella syndrome (CRS) with cardiac defects, cataracts, deafness, intellectual disability; arthralgia and arthritis (especially in adults); thrombocytopenia; myocarditis; encephalitis; immunosuppression complications in vulnerable populations
- Potential Complications: Congenital infection causing permanent fetal abnormalities; spontaneous abortion; preterm delivery; fetal growth restriction; teratogenic effects including heart disease, developmental delays, and sensory impairment
Follow-up Tests
- Rubella IgM Antibody Test: Ordered if active infection is suspected; detects acute/recent infection; typically positive 1-2 weeks after symptom onset
- Measles and Mumps IgG: Part of MMR immunity panel; assess immunity to all three components; often ordered simultaneously
- Viral Culture or RT-PCR: May be ordered to confirm acute infection; more sensitive than serology; specimens from throat, nasopharynx, or urine; timing-dependent accuracy
- Repeat IgG Testing: Recommended for borderline results; negative results with high clinical suspicion; post-vaccination immunity verification (typically tested 4-6 weeks after MMR); periodic monitoring in healthcare workers
- Amniocentesis with RT-PCR: Considered in pregnant patients with negative IgG and clinical exposure; assesses fetal infection risk; typically performed after 18 weeks gestation
- Comprehensive Metabolic Panel: May assess complications if systemic infection present; monitors organ involvement
- Monitoring Frequency: One-time test for routine immunity screening; preconception testing before pregnancy planning; prenatal testing at first visit; repeat vaccination if negative and non-pregnant; no ongoing monitoring for immune individuals
Fasting Required?
- Fasting: No
- Food and Drink: No restrictions; normal diet and hydration acceptable; food and beverages do not affect serological results
- Medications: Continue routine medications as scheduled; antivirals or antibiotics do not interfere with IgG serology results; immunosuppressive medications may affect accuracy but do not require discontinuation
- Special Instructions: Notify healthcare provider of recent blood transfusions; inform lab of recent immunizations; avoid rubella vaccination within 2 weeks of this test (may cause false negative); no specific preparation required; routine venipuncture procedures apply
- Specimen Collection: Single venipuncture; serum collection in appropriate tube (typically SST or similar separator tube); no special handling required post-collection; sample stable for transport; performed at any time of day; no time-dependent variations

How our test process works!