SARS-COV-2 Spike protein IgG Antibodies
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Measures the level of IgG antibodies directed against the spike (S) protein of the SARS-CoV-2 virus
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🧪 What is SARS-CoV-2 Spike Protein IgG Antibodies Test?
This test measures the level of IgG antibodies directed against the spike (S) protein of the SARS-CoV-2 virus in blood. The spike protein is the key viral structure enabling the virus to bind and enter human cells.
❓ Why is the Test Done?
To:
- Assess immune response after natural infection or COVID-19 vaccination
- Evaluate past exposure to SARS-CoV-2
- Help determine level of protective immunity
- Guide decisions on booster vaccination timing (though not definitive)
- Support epidemiological studies of population immunity
📊 Normal Range / Interpretation
Antibody Level | Interpretation |
|---|---|
Negative or below threshold | No detectable or low antibodies; no or waning immunity |
Positive | Evidence of past infection or successful vaccination |
High levels | Strong immune response, possibly protective |
Cutoffs vary by assay; units may be AU/mL, BAU/mL, or index values depending on test.
📈 Clinical Significance
Result | Implications |
|---|---|
Positive IgG | Prior infection or vaccination; some degree of immunity |
Negative IgG | No prior exposure or vaccine response; vulnerable to infection |
Declining levels | Possible waning immunity; booster doses may be needed |
🧠 Associated Conditions
Condition | Details |
|---|---|
COVID-19 infection | Natural antibody response to infection |
COVID-19 vaccination | Vaccine-induced immunity targeting spike protein |
Immunocompromised states | May show reduced or absent antibody response |
🔄 Related / Follow-Up Tests
- Neutralizing antibody assays – measure functional virus neutralization
- Total antibody or IgM antibody tests – for recent infection
- T-cell immunity tests – for cellular immune response
- PCR test – to detect active infection if symptomatic
✅ Fasting Required?
Test | Fasting Required |
|---|---|
SARS-CoV-2 Spike Protein IgG | ❌ No |
📝 Summary Table
Parameter | Details |
|---|---|
What | Measures IgG antibodies against SARS-CoV-2 spike protein |
Why | Assess immune response after infection or vaccination |
Normal Range | Negative or positive based on assay cutoffs |
Positive Result | Past infection or vaccination with some immunity |
Associated Conditions | COVID-19 infection, vaccination status |
Follow-up Tests | Neutralizing antibody test, PCR, T-cell assays |
Fasting Required | ❌ No |
How our test process works!
