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Scrotum - Large Biopsy 3-6 cm
Biopsy
Report in 288Hrs
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No Fasting Required
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Tissue biopsy of scrotum.
₹666₹951
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Scrotum - Large Biopsy 3-6 cm: Comprehensive Medical Test Guide
- Why is it done?
- This test involves obtaining a tissue sample from the scrotum measuring 3-6 cm for histopathological examination and diagnosis of suspicious lesions or masses
- Primary indications include evaluation of palpable nodules, suspected malignancy, persistent skin abnormalities, or masses not responsive to conservative management
- Performed when imaging studies (ultrasound, MRI) show suspicious features requiring tissue diagnosis
- Used to differentiate benign conditions from malignant neoplasms including melanoma, squamous cell carcinoma, basal cell carcinoma, or other scrotal malignancies
- Typically performed when lesions persist beyond 3-4 weeks or show signs of clinical progression
- May be indicated when patients have risk factors for scrotal malignancy, history of chemical exposure, or immunosuppression
- Normal Range
- Negative/Normal Result: Benign tissue without evidence of malignancy, infection, or significant pathology
- Specimen Adequacy: Tissue sample size of 3-6 cm with adequate material for diagnostic evaluation
- Normal Components: Presence of normal epidermal and dermal layers, normal skin appendages (hair follicles, sebaceous glands, eccrine sweat glands), with normal cellular architecture and no dysplasia
- Interpretation of Normal: Indicates benign lesion such as seborrheic keratosis, cyst, lipoma, or inflammatory condition; effectively excludes malignancy
- Measurement Units: Specimen size reported in centimeters (cm); descriptive histopathology findings documented
- Interpretation
- Benign Findings: Indicates conditions such as epidermal inclusion cysts, lipomas, hemangiomas, seborrheic keratosis, dermatitis, or other non-malignant pathology; reassuring diagnosis requiring observation only
- Malignant Findings: Identification of malignant cells with specific diagnosis (melanoma, squamous cell carcinoma, basal cell carcinoma, Paget's disease, lymphoma, or other malignancy) requiring immediate treatment planning and possible wider surgical excision
- Atypical/Dysplastic Findings: Demonstration of dysplasia or atypical features suggestive of premalignant lesion; indicates increased risk requiring close surveillance, possible re-excision, or dermatologic follow-up
- Inflammatory Findings: Presence of inflammation, infection, or granulomatous disease; may include bacterial, fungal, or other infectious organisms requiring targeted treatment
- Factors Affecting Interpretation: Specimen adequacy and orientation; patient's age, location of lesion, clinical history, and prior treatments; immune status; sun exposure history; concurrent medical conditions
- Margin Assessment: For malignant lesions, evaluation of surgical margins to determine if complete excision achieved; positive margins indicate need for re-excision
- Special Stains and Testing: May include immunohistochemistry, special stains for microorganisms, or molecular testing based on histologic findings
- Associated Organs
- Primary Organ System: Integumentary system (skin); specifically the scrotal skin and subcutaneous tissues
- Secondary Organ Systems: Lymphatic system (regional lymph nodes may be involved); reproductive system if lesion involves deeper structures
- Associated Malignancies: Melanoma (aggressive with risk of metastasis to distant organs); squamous cell carcinoma; basal cell carcinoma; extramammary Paget's disease; scrotal lymphoma; sarcoma
- Associated Benign Conditions: Epidermal inclusion cysts, lipomas, hemangiomas, lymphangiomas, varicoceles, hydroceles with skin involvement, dermatitis, eczema, psoriasis
- Infectious Conditions: Bacterial infections, fungal infections (including candidiasis, tinea), viral infections (HPV-related lesions), tuberculosis, syphilis
- Potential Complications of Abnormal Results: Cancer metastasis to regional lymph nodes, lungs, liver, brain, or bone; systemic infection if infectious organism identified; compromised reproductive or sexual function; psychological impact of cancer diagnosis
- Risk Factors for Malignancy: Chronic sun exposure, chemical exposure, prior radiation therapy, immunosuppression (HIV/AIDS, transplant recipients), smoking history, family history of skin cancer
- Follow-up Tests
- If Malignancy Diagnosed: Wide surgical excision of lesion; regional lymph node ultrasound or CT; chest imaging (X-ray or CT) for lung metastases; PET-CT for staging in melanoma or advanced cases; sentinel lymph node biopsy if indicated
- If Atypical/Dysplastic Findings: Possible re-excision with wider margins; dermatologic consultation; regular clinical monitoring every 3-6 months; patient self-examination education
- If Infectious Process Identified: Culture and sensitivity testing; organism-specific treatment; follow-up cultures to confirm cure; evaluation for systemic involvement if needed
- If Benign Results: Clinical follow-up as needed; routine skin surveillance; no additional testing unless symptoms develop
- Monitoring Frequency for Malignancy: Close follow-up every 1-3 months for first year; then every 3-6 months for years 2-5; annual surveillance indefinitely depending on stage and type; more frequent if high-risk features present
- Complementary Tests: Dermoscopy for future lesion evaluation; total body skin examination; lymph node examination; additional imaging studies based on specific diagnosis
- Molecular/Genetic Testing: BRAF mutation analysis for melanoma; microsatellite instability testing; HPV testing if HPV-related lesion identified; other specialized testing based on pathology findings
- Fasting Required?
- Fasting: No - Fasting is not required for this tissue biopsy procedure
- Anesthesia Consideration: Local anesthesia only is typically used; if conscious sedation planned, fasting may be required - confirm with provider
- Medications to Avoid: Discontinue aspirin, NSAIDs (ibuprofen, naproxen), and antiplatelet agents 3-5 days prior if possible to reduce bleeding risk; continue anticoagulants (warfarin, DOACs) unless specifically instructed otherwise; discuss all medications with provider
- Pre-procedure Preparation: Wash area with soap and water before procedure; wear loose, comfortable clothing; arrange transportation if sedation used; arrive 15-30 minutes early for check-in
- Post-procedure Instructions: Keep biopsy site clean and dry; avoid soaking in baths or pools for 1 week; do not apply ointments unless directed; use antibiotic ointment if provided; avoid strenuous activity and tight clothing for 7-10 days; watch for signs of infection
- Special Instructions: Inform provider of allergies to anesthetic agents; report any medical conditions; disclose all current medications and supplements; inform about bleeding disorders or anticoagulation therapy
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