Spot Urinary Creatinine
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Measures the concentration of creatinine in a single, random urine sample
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🧪 What is Spot Urinary Creatinine?
The Spot Urinary Creatinine test measures the concentration of creatinine in a single, random urine sample. Creatinine is a breakdown product of muscle metabolism, excreted at a relatively constant rate, and used to normalize other urinary analytes such as protein or albumin in spot samples.
❓ Why is the Test Done?
To:
- Assess kidney function indirectly
- Calculate protein-to-creatinine or albumin-to-creatinine ratios for estimating daily protein or albumin excretion without 24-hour urine collection
- Monitor renal disease progression
- Evaluate muscle mass indirectly in some clinical scenarios
📊 Normal Range
Urinary Creatinine Concentration | Reference Range |
|---|---|
Varies widely depending on hydration | Typically 50 – 300 mg/dL urine |
Urinary creatinine concentration varies with urine volume and hydration status; interpretation often in ratio form.
📈 Interpretation of Results
Finding | Clinical Significance |
|---|---|
Low urinary creatinine | Dilute urine, possible overhydration |
High urinary creatinine | Concentrated urine, dehydration |
Used in ratios | Normalizes spot urine proteins for accurate assessment |
🧠 Associated Conditions
Condition | Details |
|---|---|
Kidney disease | Used to estimate proteinuria or albuminuria |
Muscle wasting diseases | May affect creatinine production |
Hydration status | Influences urinary creatinine concentration |
🔄 Related / Follow-Up Tests
- Spot Urinary Protein or Albumin Creatinine Ratio (PCR/ACR)
- 24-hour urine creatinine and protein
- Serum creatinine and eGFR
- Urinalysis
✅ Fasting Required?
Test | Fasting Required |
|---|---|
Spot Urinary Creatinine | ❌ No |
📝 Summary Table
Parameter | Details |
|---|---|
What | Creatinine concentration in a single urine sample |
Why | Normalize urinary analytes, assess kidney function |
Normal Range | Variable; depends on hydration, typically 50–300 mg/dL |
Low Concentration | Dilute urine, overhydration |
High Concentration | Concentrated urine, dehydration |
Associated Conditions | Kidney disease, muscle mass changes, hydration status |
Follow-up Tests | PCR/ACR, 24-hour urine protein, serum creatinine |
Fasting Required | ❌ No |
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