jamunjar-logo
whatsapp
cartmembermenu
Search for
"test & packages"
"physiotherapy"
"heart"
"lungs"
"diabetes"
"kidney"
"liver"
"cancer"
"thyroid"
"bones"
"fever"
"vitamin"
"iron"
"HTN"

Super Advanced - Bone Profile

Bone

11 parameters

image

Report in 12Hrs

image

At Home

nofastingrequire

No Fasting Required

Details

Includes markers of bone turnover & resorption.

₹2,299₹3,357

32% OFF

Parameters

  • List of Tests
    • Calcium
    • Alkaline Phosphatase
    • Magnesium
    • Phosphorous
    • ANA
    • 25 OH Vitamin D
    • Vitamin B12
    • Zinc (Serum)
    • Uric Acid
    • RF
    • Anti - CCP (ACCP)

Super Advanced - Bone Profile

  • Why is it done?
    • Comprehensive assessment of bone health, mineral metabolism, and autoimmune/inflammatory markers affecting skeletal integrity
    • Evaluation of mineral markers (Calcium, Phosphorous, Magnesium) essential for bone formation, maintenance, and remodeling
    • Assessment of vitamin D status (25 OH Vitamin D) which regulates calcium absorption and bone mineralization
    • Detection of bone remodeling through Alkaline Phosphatase measurement, indicating osteoblast activity
    • Evaluation of autoimmune arthropathies (ANA, RF, Anti-CCP) that compromise bone and joint integrity
    • Assessment of micronutrient status (Vitamin B12, Zinc, Uric Acid) affecting bone metabolism and immune function
    • Diagnosis and monitoring of osteoporosis, osteopenia, metabolic bone disease, and inflammatory arthropathies
    • Screening for rickets, hyperparathyroidism, hypoparathyroidism, and chronic kidney disease complications
    • Investigation of chronic musculoskeletal pain, joint inflammation, and recurrent fractures
    • Monitoring patients on corticosteroid therapy, anticonvulsants, or other bone-affecting medications
  • Normal Range
    • Calcium: 8.5-10.2 mg/dL (2.12-2.55 mmol/L); Normal indicates adequate mineral stores for bone integrity and cellular function
    • Alkaline Phosphatase: 44-147 IU/L (0.73-2.45 µkat/L); Normal range reflects appropriate bone turnover and osteoblast activity
    • Magnesium: 1.7-2.2 mg/dL (0.70-0.90 mmol/L); Normal indicates sufficient magnesium for bone formation and neuromuscular function
    • Phosphorous: 2.5-4.5 mg/dL (0.81-1.45 mmol/L); Normal range supports calcium-phosphate balance for bone mineralization
    • ANA (Antinuclear Antibody): Negative or <1:80 titer; Negative result excludes systemic autoimmune diseases
    • 25 OH Vitamin D: 30-100 ng/mL (75-250 nmol/L); Normal range ensures optimal calcium absorption and immune regulation
    • Vitamin B12: 200-900 pg/mL (148-664 pmol/L); Normal level supports neurological function and bone marrow health
    • Zinc (Serum): 60-120 µg/dL (9.2-18.5 µmol/L); Normal range essential for immune function and bone metabolism
    • Uric Acid: 3.5-7.2 mg/dL (208-428 µmol/L); Normal range prevents gout and crystal arthropathy complications
    • Rheumatoid Factor (RF): <14 IU/mL; Negative result excludes or makes rheumatoid arthritis less likely
    • Anti-CCP (ACCP): <20 U/mL; Negative result indicates absence of anti-cyclic citrullinated peptide antibodies suggestive of rheumatoid arthritis
  • Interpretation
    • Calcium - Low (<8.5 mg/dL): Hypocalcemia indicating hypoparathyroidism, vitamin D deficiency, kidney disease, or malabsorption; increases fracture risk. High (>10.2 mg/dL): Hypercalcemia from hyperparathyroidism, excessive vitamin D, or malignancy; causes bone resorption and kidney complications
    • Alkaline Phosphatase - Low (<44 IU/L): Hypophosphatasia, malnutrition, or hypothyroidism reducing bone formation. High (>147 IU/L): Increased bone turnover from osteoporosis, Paget's disease, rickets, healing fractures, liver disease, or bone malignancy
    • Magnesium - Low (<1.7 mg/dL): Hypomagnesemia from malabsorption, diuretics, or diarrhea; impairs bone mineralization and increases fracture susceptibility. High (>2.2 mg/dL): Rare except in kidney disease; inhibits parathyroid hormone secretion affecting calcium homeostasis
    • Phosphorous - Low (<2.5 mg/dL): Hypophosphatemia from malnutrition, hyperparathyroidism, or vitamin D deficiency; reduces bone mineralization. High (>4.5 mg/dL): Hyperphosphatemia indicating kidney disease, hypoparathyroidism, or excessive vitamin D supplementation
    • ANA - Negative: Normal; excludes systemic lupus erythematosus and related autoimmune connective tissue diseases. Positive (≥1:80): Suggests systemic lupus erythematosus, Sjögren's syndrome, scleroderma, or mixed connective tissue disease; pattern interpretation (homogeneous, speckled, nucleolar) helps differentiate diagnoses
    • 25 OH Vitamin D - Deficient (<20 ng/mL): Risk for rickets, osteomalacia, and impaired immune function affecting bone and joint health. Insufficient (20-29 ng/mL): Suboptimal bone mineralization and increased infection susceptibility. Adequate (30-100 ng/mL): Normal bone metabolism and immune function. Excess (>100 ng/mL): Hypercalcemia risk causing bone resorption and renal calculi
    • Vitamin B12 - Low (<200 pg/mL): Deficiency causing pernicious anemia, neuropathy, reduced osteoblast function, and increased fracture risk. Normal (200-900 pg/mL): Adequate neurological and hematological function. High (>900 pg/mL): Unusual; may indicate myeloproliferative disorders or recent supplementation
    • Zinc (Serum) - Low (<60 µg/dL): Deficiency impairing bone formation, immune function, and wound healing; increases fracture susceptibility. Normal (60-120 µg/dL): Adequate bone metabolism and immune response. High (>120 µg/dL): Copper deficiency risk or excessive supplementation causing anemia and neurological complications
    • Uric Acid - Low (<3.5 mg/dL): Xanthinuria, allopurinol use, or liver disease; rarely causes clinical problems. Normal (3.5-7.2 mg/dL): No gout or urate crystal deposition. High (>7.2 mg/dL): Hyperuricemia increasing gout risk causing acute arthritis, chronic tophaceous arthropathy, and joint destruction
    • Rheumatoid Factor (RF) - Negative (<14 IU/mL): Normal; excludes rheumatoid arthritis. Positive (≥14 IU/mL): Indicates rheumatoid arthritis, other autoimmune diseases, or chronic infections; higher titers correlate with disease severity and joint erosion
    • Anti-CCP (ACCP) - Negative (<20 U/mL): Excludes rheumatoid arthritis. Positive (≥20 U/mL): Highly specific for rheumatoid arthritis; positive result predicts joint erosion, worse prognosis, and need for aggressive DMARD therapy; more specific than RF for RA diagnosis
  • Associated Organs
    • Calcium: Skeletal system, kidneys, and intestines; primary organ affected is bone. Abnormalities cause osteoporosis, osteomalacia, hypocalcemic seizures, and cardiac arrhythmias
    • Alkaline Phosphatase: Bone, liver, and intestines; reflects bone remodeling activity. Elevated levels indicate accelerated osteoblast activity in healing fractures, rickets, osteoporosis, or hepatic disease
    • Magnesium: Skeletal system, parathyroid glands, muscles, and nervous system. Deficiency impairs bone formation, causes hypokalemia refractory to treatment, and increases risk of sudden cardiac death
    • Phosphorous: Skeleton, kidneys, and parathyroid glands; critical for bone mineralization and energy metabolism. Abnormalities impair osteoid mineralization and cause secondary hyperparathyroidism in kidney disease
    • ANA: Immune system; detects systemic autoimmune diseases affecting multiple organs including bones, joints, skin, kidneys, and lungs. Positive result indicates systemic inflammation potentially causing lupus arthritis and bone loss
    • 25 OH Vitamin D: Small intestine (absorption site), kidneys (activation), skin (synthesis), and skeleton. Deficiency causes rickets in children, osteomalacia in adults, secondary hyperparathyroidism, and impaired immune defense
    • Vitamin B12: Gastrointestinal tract (absorption), bone marrow, spinal cord, and peripheral nerves. Deficiency causes pernicious anemia, subacute combined degeneration, impaired osteoblast function, and increased bone loss
    • Zinc (Serum): Skeleton, immune system, gastrointestinal tract, and skin. Deficiency impairs bone formation, weakens immune response increasing infection risk, causes dermatitis, and delays wound healing
    • Uric Acid: Skeletal system (gout), kidneys (excretion), and joints. Hyperuricemia causes acute arthritis, tophaceous gout with joint destruction, urate nephropathy, and chronic renal disease
    • Rheumatoid Factor (RF): Immune system and joints; marker of autoimmune disease affecting multiple organs. Positive RF causes rheumatoid arthritis with progressive joint erosion, systemic vasculitis, and extra-articular complications
    • Anti-CCP (ACCP): Immune system and joints; highly specific for rheumatoid arthritis pathology. Positive Anti-CCP predicts severe progressive joint erosion, cartilage destruction, and permanent disability if untreated
  • Follow-up Tests
    • Calcium abnormalities: Ionized calcium, parathyroid hormone (PTH), intact PTH, 24-hour urinary calcium, and serum creatinine for renal function assessment; consider imaging including skull and hand radiographs for hyperparathyroidism
    • Alkaline Phosphatase elevation: Bone-specific alkaline phosphatase, liver function tests (ALT, AST, GGT), PTH, vitamin D level, alkaline phosphatase isoenzymes, and bone imaging if metabolic bone disease suspected
    • Magnesium abnormalities: Serum potassium, calcium levels, PTH, electrocardiogram for cardiac monitoring, 24-hour urinary magnesium, and assessment of chronic diarrhea or medications causing losses
    • Phosphorous abnormalities: PTH, alkaline phosphatase, creatinine and estimated glomerular filtration rate for renal function, calcium levels, and imaging studies for hyperparathyroidism or malignancy
    • ANA positive result: Anti-dsDNA, anti-Smith antibodies, complement levels (C3, C4), CBC with differential, comprehensive metabolic panel, urinalysis for lupus nephritis, and chest radiography for pulmonary involvement
    • Vitamin D deficiency: PTH level, calcium, alkaline phosphatase, bone-specific alkaline phosphatase, P1NP (procollagen type 1 N-terminal propeptide), CTX (C-terminal telopeptide), and DEXA scan for bone density assessment
    • Vitamin B12 deficiency: Methylmalonic acid, homocysteine, intrinsic factor and parietal cell antibodies for pernicious anemia, CBC for megaloblastic anemia, and neurological assessment for subacute combined degeneration
    • Zinc deficiency: Serum prealbumin, albumin, complete blood count for immune cell evaluation, assessment of gastrointestinal absorption, dietary evaluation, and skin biopsy if dermatitis present
    • Uric acid elevation: 24-hour urinary uric acid, creatinine and renal function tests, comprehensive metabolic panel, calcium oxalate and uric acid crystals in urine, imaging for tophi, and arthritis markers if gout suspected
    • Rheumatoid Factor positive: Anti-CCP antibodies (for diagnostic confirmation), ESR, CRP, complete blood count, comprehensive metabolic panel, X-rays of affected joints for erosion assessment, and ultrasound for synovitis evaluation
    • Anti-CCP positive: Rheumatoid factor confirmation, ESR, CRP, CBC with differential, comprehensive metabolic panel, X-rays and MRI of hands/feet for early erosion detection, and baseline assessment before DMARD initiation
    • General recommendation: Repeat testing annually or as clinically indicated based on diagnosis; monitor medication effects; repeat bone profile every 6-12 months if on bisphosphonates or other bone-active agents
  • Fasting Required?
    • Fasting: YES - 8-12 hours recommended (ideally overnight fasting from 10 PM to 8 AM for morning collection)
    • Avoid medications: Hold calcium supplements, vitamin D supplements, multivitamins, and mineral supplements for 24 hours before testing to avoid falsely elevated mineral levels
    • Dietary restrictions: Avoid high-fat meals 12 hours before testing; avoid excessive calcium-rich dairy products 24 hours prior; continue normal diet but do not consume heavy breakfast before fasting draw
    • Hydration: Drink water freely during fasting period; adequate hydration improves blood sample quality and reduces hemolysis affecting result accuracy
    • Timing considerations: Early morning collection (7-9 AM) preferred for optimal circadian variation accuracy; morning samples show less time-dependent variation in mineral levels
    • Physical activity: Avoid strenuous exercise 24 hours before testing as physical stress affects uric acid, alkaline phosphatase, and other metabolic markers
    • Alcohol and caffeine: Avoid alcohol 24 hours before testing; caffeine acceptable but limit to minimal intake as it may affect mineral metabolism
    • Sample collection: Blood drawn by venipuncture into appropriate collection tubes (SST serum separator tubes or plain tubes without additives for mineral and autoimmune markers)
    • Special medications to discuss: Inform phlebotomist/physician about bisphosphonates, hormone replacement therapy, corticosteroids, anticonvulsants, and thiazide diuretics as these affect bone metabolism markers
    • Consistency in timing: For serial monitoring, collect samples at approximately same time of day and same day of week to minimize variation from circadian rhythms and weekly activity patterns

How our test process works!

customers
customers