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Syphilis TP

Reproductive
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Report in 4Hrs

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At Home

nofastingrequire

No Fasting Required

Details

Used to confirm syphilis infection by identifying specific antibodies.

₹1,149₹1,400

18% OFF

Syphilis TP - Comprehensive Medical Test Information Guide

  • Why is it done?
    • Detects antibodies against Treponema pallidum, the bacterium that causes syphilis infection
    • Diagnoses syphilis in patients presenting with clinical symptoms such as genital ulcers, rash, or lymphadenopathy
    • Routine screening during prenatal care to prevent congenital syphilis transmission
    • Required screening for blood and organ donors to ensure transfusion safety
    • Contact tracing in patients with confirmed syphilis diagnosis
    • Monitoring response to antibiotic treatment in previously diagnosed cases
    • Risk stratification in patients with high-risk sexual behavior or multiple partners
  • Normal Range
    • Normal/Negative Result: Non-reactive or negative - indicates no detection of Treponema pallidum antibodies
    • Abnormal/Positive Result: Reactive or positive - indicates presence of antibodies to Treponema pallidum
    • Units of Measurement: Qualitative (positive/negative) or semi-quantitative (titers expressed as dilutions, e.g., 1:4, 1:8, 1:16)
    • Interpretation Guidance: Negative/non-reactive result means no evidence of current or past syphilis infection; positive result requires confirmation with treponemal-specific testing such as FTA-ABS or TP-PA
  • Interpretation
    • Negative/Non-reactive Result: No syphilis infection detected; however, false negatives can occur during the window period (first 3-4 weeks after infection) or in severely immunocompromised patients
    • Positive/Reactive Result: Indicates exposure to Treponema pallidum; requires confirmation with specific treponemal tests; may indicate active infection or past infection with lifelong antibody persistence
    • High Titer Results (≥1:8): Suggests active or recent infection; often seen in primary, secondary, or early latent syphilis; indicates higher likelihood of treatment requirement
    • Low Titer Results (<1:8): May indicate late latent or treated syphilis; possible false positive; should be correlated with clinical presentation and confirmed with treponemal testing
    • Factors Affecting Results: Immunocompromised status, HIV co-infection, advanced disease, biological false positives (autoimmune diseases, malignancy, recent vaccinations), pregnancy, age, and time since infection
    • Clinical Significance: This is typically a screening test; confirmation requires treponemal-specific tests to differentiate active from past infection and avoid false positives from autoimmune conditions
  • Associated Organs
    • Primary Organ Systems Affected: Genital/reproductive system, skin, central nervous system (CNS), cardiovascular system, bone and joints
    • Diseases Diagnosed or Monitored: Primary syphilis (chancre), secondary syphilis (rash and systemic symptoms), latent syphilis (asymptomatic), tertiary syphilis (gummas, neurosyphilis, cardiovascular involvement)
    • Congenital Syphilis: Can affect fetal development causing fetal death, prematurity, low birth weight, structural abnormalities, and long-term complications in the neonate
    • Neurosyphilis Complications: Meningitis, general paresis of the insane (GPI), tabes dorsalis, optic neuritis, hearing loss
    • Cardiovascular Complications: Aortitis, aortic regurgitation, coronary artery stenosis, aortic aneurysm
    • Musculoskeletal Involvement: Periostitis, arthritis, osteitis; gummatous lesions in bone
    • Risk of Serious Complications: Significantly increased in patients with HIV co-infection or advanced immunosuppression; higher risk of neurosyphilis and treatment failures
  • Follow-up Tests
    • Confirmatory Treponemal Tests: FTA-ABS (Fluorescent Treponemal Antibody Absorption), TP-PA (Treponema pallidum Particle Agglutination), or TP-EIA (Enzyme Immunoassay) to confirm positive TP screening results
    • Quantitative Non-Treponemal Tests: RPR (Rapid Plasma Reagin) or VDRL (Venereal Disease Research Laboratory) to determine titer levels and assess disease activity
    • HIV Testing: Recommended for all patients with confirmed syphilis as co-infection affects treatment and monitoring
    • Cerebrospinal Fluid (CSF) Analysis: Indicated if neurosyphilis is suspected; includes VDRL, protein, glucose, and cell count
    • Darkfield Microscopy: Direct visualization of treponemes from primary lesion exudate for immediate diagnosis
    • Cardiovascular Assessment: EKG and chest X-ray if tertiary syphilis with cardiovascular involvement is suspected
    • Follow-up Serology: Repeat non-treponemal testing at 3, 6, and 12 months post-treatment; fourfold decline in titers indicates adequate treatment response
    • Other Screening Tests: Hepatitis B and C serology, herpes simplex virus (HSV) testing, gonorrhea screening as indicated
  • Fasting Required?
    • Fasting Requirement: No
    • Fasting Duration: Not applicable; patient may eat and drink normally before blood collection
    • Medications to Avoid: None specifically required; however, ongoing antibiotic therapy should be noted as it may affect test interpretation
    • Patient Preparation Instructions: No special preparation needed; patient should provide blood sample via venipuncture; inform healthcare provider of all current medications and any recent infections or vaccinations
    • Specimen Collection Details: Blood sample collected in standard serum separator tube (SST) or equivalent; no special handling required

How our test process works!

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