Thyroid Profile

Thyroid

3 parameters

Report in 4Hrs

At Home

No Fasting Required

Details

Measures T3, T4, TSH.

₹129₹495

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Parameters

List of Tests
- Total T3
- Total T4
- TSH

Thyroid Profile

Why is it done?
- Comprehensive assessment of thyroid gland function and hormone production to diagnose thyroid disorders
- TSH (Thyroid-Stimulating Hormone) screens for primary thyroid dysfunction by measuring the pituitary gland's signal to the thyroid
- Total T4 measures the total thyroid hormone bound to proteins plus free hormone to assess thyroid hormone production capacity
- Total T3 evaluates the active form of thyroid hormone that drives metabolism and energy production
- Diagnoses hypothyroidism (underactive thyroid) and hyperthyroidism (overactive thyroid)
- Evaluates symptoms such as fatigue, weight changes, temperature sensitivity, mood changes, and heart palpitations
- Monitors existing thyroid disease and medication efficacy in patients on thyroid hormone replacement or antithyroid drugs
- Investigates fertility issues, pregnancy complications, or metabolic disorders
- Screens patients with autoimmune conditions, depression, or cardiac arrhythmias for thyroid dysfunction
- Three tests work together to differentiate primary thyroid disease from secondary (pituitary-related) thyroid dysfunction
Normal Range
- TSH (Thyroid-Stimulating Hormone): 0.4 to 4.0 mIU/L (milliunits per liter) - Normal range indicates appropriate pituitary-thyroid axis feedback
- Total T4 (Thyroxine): 5.0 to 12.0 mcg/dL (micrograms per deciliter) or 64.4 to 154.5 nmol/L (nanomoles per liter) - Reflects total circulating T4 bound to proteins and free hormone
- Total T3 (Triiodothyronine): 80 to 200 ng/dL (nanograms per deciliter) or 1.2 to 3.1 nmol/L - Represents total T3 bound to proteins and free circulating T3
- Normal results indicate the thyroid is producing adequate hormone and the pituitary feedback mechanism is functioning properly
- Reference ranges may vary slightly between laboratories based on assay methodology and population-specific data
- Age, sex, pregnancy status, and certain medications can influence interpretation of normal ranges
Interpretation
- TSH Elevated (>4.0 mIU/L): Suggests primary hypothyroidism (thyroid not producing enough hormone), causing pituitary to increase TSH stimulation; T4 levels will be low or low-normal
- TSH Low (<0.4 mIU/L): Indicates hyperthyroidism or over-replacement with thyroid hormone; typically accompanied by elevated T3 and T4
- Total T4 Elevated (>12.0 mcg/dL): Indicates hyperthyroidism, increased thyroid hormone production, thyroiditis, or excessive hormone replacement; associated with weight loss, tachycardia, and anxiety
- Total T4 Low (<5.0 mcg/dL): Indicates hypothyroidism, iodine deficiency, or inadequate thyroid hormone replacement; causes fatigue, weight gain, and cold sensitivity
- Total T3 Elevated (>200 ng/dL): Occurs in hyperthyroidism, T3 thyrotoxicosis, excessive iodine intake, or T3 hormone replacement; more sensitive indicator of hyperthyroidism than T4
- Total T3 Low (<80 ng/dL): May indicate hypothyroidism, chronic illness, malnutrition, or certain medications; less commonly used for diagnosis but supports hypothyroidism assessment
- Secondary hypothyroidism: TSH low with low T4 indicates pituitary or hypothalamic dysfunction rather than primary thyroid disease
- Subclinical hypothyroidism: Elevated TSH with normal T4 and T3 may progress to overt hypothyroidism requiring treatment
- Binding protein abnormalities: Low or high total T4 and T3 can occur without thyroid dysfunction if binding protein levels are altered (estrogen, androgens, liver disease)
Associated Organs
- Thyroid Gland: Primary organ of focus - butterfly-shaped gland in the neck producing T3, T4, and calcitonin; regulated by TSH from pituitary gland
- Pituitary Gland: Produces TSH which controls thyroid hormone release; TSH levels reflect pituitary-thyroid axis communication
- Hypothalamus: Produces TRH (Thyrotropin-Releasing Hormone) which stimulates pituitary TSH production; part of endocrine regulation axis
- Heart: Thyroid hormones increase cardiac contractility and heart rate; hyperthyroidism increases risk of atrial fibrillation and heart disease
- Metabolic system: Thyroid hormones regulate basal metabolic rate, affecting weight, temperature, and energy levels throughout the body
- Brain and Nervous System: Thyroid hormones affect mood, cognition, concentration, and neurological function; hypothyroidism causes depression and cognitive decline
- Reproductive System: Thyroid dysfunction affects fertility, menstrual regularity, and pregnancy outcomes; critical for fetal development
- Bone and Mineral Metabolism: Excess thyroid hormone increases bone turnover and osteoporosis risk; affects calcium metabolism
- Liver: Primary site of T4 to T3 conversion (peripheral conversion); liver disease affects thyroid hormone metabolism
- Thyroid disorders include Hashimoto's thyroiditis (autoimmune hypothyroidism), Graves' disease (autoimmune hyperthyroidism), thyroid nodules, goiter, and thyroid cancer
Follow-up Tests
- Free T4 (FT4) and Free T3 (FT3): Measures unbound hormone not affected by protein binding; more accurate than total T3/T4 for diagnosis when binding proteins abnormal
- Thyroid Peroxidase (TPO) Antibodies: Tests for autoimmune thyroiditis; positive indicates Hashimoto's disease or increased autoimmune thyroid risk
- Thyroglobulin Antibodies: Identifies autoimmune thyroid disease; helps confirm Hashimoto's diagnosis when TPO antibodies present
- TSI (Thyroid Stimulating Immunoglobulin) or TRAb (TSH Receptor Antibodies): Confirms Graves' disease when elevated TSH and T3/T4 abnormalities detected
- Thyroid Ultrasound: Imaging study recommended when TSH abnormal with nodules detected or when suspecting thyroid cancer or structural disease
- TSH Receptor Antibody Assay: Useful in distinguishing Graves' disease from other causes of hyperthyroidism when clinical diagnosis uncertain
- Radioactive Iodine Uptake Test: Determines whether hyperthyroidism due to Graves' disease, thyroiditis, or iodine excess
- Repeat TSH testing: Typically 6-8 weeks after starting hypothyroidism treatment to verify adequate hormone replacement; continue monitoring every 6-12 months
- Lipid panel and glucose testing: Recommended in new hypothyroidism diagnosis as thyroid dysfunction increases cardiovascular and metabolic disease risk
- Pregnancy TSH screening: Separate trimester-specific ranges used; TSH monitoring essential during pregnancy due to fetal thyroid development needs
Fasting Required?
- No - Fasting is NOT required for the Thyroid Profile (TSH, Total T4, Total T3 tests)
- Blood can be collected at any time of day; food intake does not significantly affect thyroid hormone levels or TSH measurement
- Medications that should be reported: Thyroid hormone replacement (levothyroxine), antithyroid drugs (PTU, methimazole), beta-blockers, amiodarone, lithium, and corticosteroids affect results
- Levothyroxine dosing: If on thyroid hormone replacement, take regularly as directed; timing relative to blood draw less critical than consistent dosing
- Calcium and iron supplements: Separate from levothyroxine by at least 4 hours as they reduce thyroid hormone absorption
- Biotin supplements: Can falsely lower TSH results; discontinue at least 1-2 days before testing if taking high-dose biotin
- Iodine intake: Limit iodine-containing foods (seaweed, kelp) 24 hours before testing for most accurate TSH measurement
- Timing for repeat testing: Morning collection preferred for consistency; collect at similar time of day as baseline test for meaningful comparison
- Recent contrast dye: Iodinated contrast agents can temporarily elevate TSH; wait 4-6 weeks after contrast procedures before thyroid testing
- Special preparation: Simply arrive for blood draw; normal daily routine and meals do not interfere with test accuracy

How our test process works!