Tissue Transglutaminase - Iga (TTG)
Report in 24Hrs
At Home
Details
Detects IgA antibodies against tissue transglutaminase, an enzyme involved in the autoimmune response in celiac disease
₹399₹1210
67% OFF
1000+ Booked this Test
🧪 What is Tissue Transglutaminase IgA (tTG-IgA)?
The tTG-IgA test detects IgA antibodies against tissue transglutaminase, an enzyme involved in the autoimmune response in celiac disease. It is a highly sensitive and specific serological marker used for screening and diagnosis.
❓ Why is the Test Done?
To:
- Screen for celiac disease in patients with symptoms such as diarrhea, weight loss, and malabsorption
- Confirm diagnosis of celiac disease along with intestinal biopsy
- Monitor adherence to a gluten-free diet and disease activity
- Evaluate patients with associated autoimmune disorders or first-degree relatives of celiac patients
📊 Normal Range
tTG-IgA Level | Interpretation |
|---|---|
Negative or below cutoff | No evidence of celiac disease |
Positive (above cutoff) | Suggestive of celiac disease |
Cutoff values vary by assay and laboratory.
📈 Interpretation of Results
Result | Clinical Implications |
|---|---|
Positive tTG-IgA | Strongly suggestive of celiac disease |
Negative tTG-IgA | Celiac disease unlikely, unless IgA deficiency present |
False negatives | Possible in IgA deficiency; consider total IgA measurement |
🧠 Associated Conditions
Condition | Details |
|---|---|
Celiac disease | Autoimmune gluten-sensitive enteropathy |
IgA deficiency | May cause false-negative tTG-IgA test |
Other autoimmune diseases | Associated autoimmune conditions (thyroid, type 1 diabetes) |
🔄 Related / Follow-Up Tests
- Total serum IgA – to exclude IgA deficiency
- Endomysial antibody (EMA) test – confirmatory test
- Small bowel biopsy – gold standard for diagnosis
- Genetic testing (HLA-DQ2/DQ8) – supportive diagnosis
- Anti-tTG IgG – useful if IgA deficient
✅ Fasting Required?
Test | Fasting Required |
|---|---|
tTG-IgA | ❌ No |
📝 Summary Table
Parameter | Details |
|---|---|
What | IgA antibodies against tissue transglutaminase enzyme |
Why | Screen and diagnose celiac disease |
Normal Range | Negative or below cutoff |
Positive Result | Suggestive of celiac disease |
Associated Conditions | Celiac disease, IgA deficiency |
Follow-up Tests | Total IgA, EMA, biopsy, genetic testing |
Fasting Required | ❌ No |
How our test process works!
