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🧪 What is Total Iron Binding Capacity (TIBC)?

TIBC measures the blood’s capacity to bind iron with transferrin, the main iron transport protein. It reflects the amount of transferrin available to bind iron and is used to evaluate iron metabolism and iron status.

❓ Why is the Test Done?

To:

Diagnose and differentiate types of anemia, especially iron deficiency anemia
Assess iron overload conditions
Evaluate transferrin saturation (ratio of serum iron to TIBC)
Monitor iron therapy effectiveness

📊 Normal Range

TIBC Level	Reference Range
Adults	240 – 450 µg/dL (43 – 81 µmol/L)

Reference ranges may vary slightly by laboratory.

📈 Interpretation of Results

TIBC Level	Clinical Significance
High TIBC	Iron deficiency anemia (transferrin production increased)
Low TIBC	Chronic disease anemia, iron overload, malnutrition
Normal TIBC	Normal iron binding capacity

🧠 Associated Conditions

Condition	Details
Iron deficiency anemia	Elevated TIBC due to increased transferrin production
Anemia of chronic disease	Low or normal TIBC due to reduced transferrin synthesis
Hemochromatosis	Low TIBC with high serum iron
Liver disease	May affect transferrin production

🔄 Related / Follow-Up Tests

Serum iron
Transferrin saturation (serum iron / TIBC ratio)
Serum ferritin
Complete blood count (CBC)

✅ Fasting Required?

Test	Fasting Required
TIBC	❌ No

📝 Summary Table

Parameter	Details
What	Measures iron binding capacity of transferrin in blood
Why	Diagnose iron deficiency or overload
Normal Range	240–450 µg/dL
High TIBC	Iron deficiency anemia
Low TIBC	Chronic disease anemia, iron overload
Associated Conditions	Iron deficiency, anemia of chronic disease, hemochromatosis
Follow-up Tests	Serum iron, transferrin saturation, ferritin
Fasting Required	❌ No

Total Iron Binding Capacity (TIBC)

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