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🧪 What is TSH Receptor Antibody (IgG)?

The TSH Receptor Antibody (TSHR Ab) test measures IgG antibodies directed against the thyroid-stimulating hormone (TSH) receptor on thyroid cells. These antibodies can stimulate or block the receptor, affecting thyroid function.

❓ Why is the Test Done?

To:

Diagnose and monitor Graves’ disease (autoimmune hyperthyroidism)
Differentiate Graves’ disease from other causes of hyperthyroidism
Predict risk of thyroid-associated ophthalmopathy
Assess risk of neonatal thyrotoxicosis in pregnant women with Graves’ disease
Monitor treatment response and disease activity

📊 Normal Range

TSH Receptor Antibody Level	Reference Range
Negative	< 1.75 IU/L (varies by lab)
Positive	≥ 1.75 IU/L

📈 Interpretation of Results

Result	Clinical Significance
Positive TSHR Ab	Indicative of Graves’ disease and active autoimmune hyperthyroidism
Negative TSHR Ab	Graves’ disease unlikely; other causes of thyroid dysfunction considered

🧠 Associated Conditions

Condition	Details
Graves’ disease	Autoimmune hyperthyroidism
Thyroid-associated ophthalmopathy	Eye involvement linked to Graves’ disease
Neonatal thyrotoxicosis	Transplacental antibody transfer causing fetal hyperthyroidism

🔄 Related / Follow-Up Tests

Thyroid function tests (TSH, Free T4, Free T3)
Thyroid peroxidase antibody (Anti-TPO)
Thyroglobulin antibody (Anti-Tg)
Thyroid ultrasound
Clinical assessment of ophthalmopathy

✅ Fasting Required?

Test	Fasting Required
TSH Receptor Antibody (IgG)	❌ No

📝 Summary Table

Parameter	Details
What	Measures IgG antibodies against TSH receptor
Why	Diagnose and monitor Graves’ disease
Normal Range	Negative: <1.75 IU/L
Positive Result	Indicates Graves’ disease
Associated Conditions	Graves’ disease, thyroid eye disease, neonatal thyrotoxicosis
Follow-up Tests	TSH, Free T4, Free T3, Anti-TPO, thyroid ultrasound
Fasting Required	❌ No

TSH - Receptor Antibody (IgG)

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