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Urinary Urea Spot

Kidney
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Report in 4Hrs

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At Home

nofastingrequire

No Fasting Required

Details

This test helps evaluate kidney function, protein metabolism, and hydration status

₹199₹250

20% OFF

Urinary Urea Spot Test Information Guide

  • Why is it done?
    • Measures the concentration of urea nitrogen in a single urine sample to assess protein metabolism and kidney function
    • Evaluates protein catabolism and nutritional status in various clinical conditions
    • Assists in monitoring patients with kidney disease, liver disease, or malnutrition
    • Helps determine the protein catabolic rate (PCR) in dialysis patients
    • Typically ordered when evaluating renal function, dietary protein adequacy, or nutritional assessment
    • Performed during routine clinical evaluations or as part of comprehensive kidney and metabolic assessments
  • Normal Range
    • Normal urinary urea nitrogen excretion: 10-16 grams per 24 hours (or approximately 7-10 mmol/L in spot urine)
    • Spot urine urea typically ranges from 2-3 mmol/L or 12-18 grams/24 hours equivalent, depending on protein intake
    • Units of Measurement: g/24h (grams per 24 hours), mmol/L (millimoles per liter), or mg/dL
    • Normal results indicate adequate protein metabolism and generally normal kidney function with appropriate protein intake
    • High values may indicate increased protein intake, hypermetabolism, fever, infection, or tissue breakdown
    • Low values may suggest low protein intake, malnutrition, liver disease, or kidney disease with decreased protein metabolism
  • Interpretation
    • Elevated Urea Levels: May indicate high protein intake, increased protein catabolism from surgery or trauma, fever, sepsis, hyperthyroidism, or increased metabolic activity
    • Decreased Urea Levels: May reflect low protein diet, malnutrition, liver disease with impaired urea synthesis, advanced kidney disease, or reduced metabolic rate
    • Factors Affecting Results: Dietary protein intake (primary factor), hydration status, physical activity, metabolic state, medications, age, sex, time of day collection, and muscle mass
    • Clinical Significance in Dialysis Patients: Spot urine urea is used to calculate protein catabolic rate (PCR/nPCR) to assess protein intake and nutritional status; low values may indicate inadequate protein intake or protein malnutrition
    • Spot vs. 24-Hour Collection: Spot urine provides single-time estimation; 24-hour collection provides more comprehensive assessment but spot samples are more convenient and practical
    • Results must be interpreted within clinical context considering patient's medical history, current symptoms, medications, and other laboratory findings
  • Associated Organs
    • Primary Organ Systems: Kidneys, liver, and muscular system; test reflects overall protein metabolism
    • Kidney Function: Kidneys filter urea from blood; abnormal urinary urea may indicate glomerular filtration rate changes or tubular dysfunction
    • Liver Function: Liver synthesizes urea from ammonia; cirrhosis or hepatic failure reduces urea production and urinary excretion
    • Diseases Diagnosed/Monitored: Chronic kidney disease, acute kidney injury, end-stage renal disease, liver cirrhosis, protein malnutrition, diabetes mellitus with complications, hypertension with renal involvement
    • Metabolic disorders, sepsis, trauma, burn injuries, and conditions affecting protein metabolism
    • Potential Complications: Severely low urea may indicate hepatic encephalopathy risk; persistently abnormal values may necessitate dialysis or nutritional intervention
  • Follow-up Tests
    • 24-Hour Urinary Urea Collection: More comprehensive assessment of daily protein metabolism and protein catabolic rate calculation
    • Serum Creatinine and BUN: Assess kidney function; BUN/creatinine ratio helps differentiate pre-renal from intrinsic kidney disease
    • Serum Albumin and Total Protein: Evaluate nutritional status and protein reserves
    • Liver Function Tests (AST, ALT, alkaline phosphatase): If liver disease suspected as cause of low urinary urea
    • Glomerular Filtration Rate (GFR) Estimation: Assess kidney function stage and progression
    • Urinary Creatinine: Normalize urea results; calculate urea-to-creatinine ratio for better assessment
    • Prealbumin (Transthyretin): More sensitive marker of recent protein status and nutritional changes
    • Monitoring Frequency: In dialysis patients, typically monitored monthly; in CKD patients, quarterly to annually depending on stage; more frequently if results significantly abnormal
  • Fasting Required?
    • Fasting Required: No - fasting is not required for urinary urea spot test collection
    • Patient Preparation Instructions: Collect random spot urine sample in clean, sterile container; mid-stream collection preferred to minimize contamination
    • For most accurate results, if 24-hour collection is planned instead, patient should void first morning urine and begin collection from next void
    • Medications: No medications need to be withheld for spot urine collection; continue all regular medications as prescribed
    • Dietary Considerations: No dietary restrictions required; however, results reflect current protein intake, so note patient's typical diet pattern
    • Timing of Collection: Spot samples can be collected at any time; however, second morning void is often preferred for consistency
    • Sample Handling: Deliver sample to laboratory promptly; refrigerate if delay anticipated; samples should reach lab within 24 hours
    • No special precautions or preservatives typically required for routine spot urine urea analysis

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