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Urinary Uric Acid (Spot)
Kidney
Report in 4Hrs
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No Fasting Required
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Spot uric acid test.
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Urinary Uric Acid (Spot) - Comprehensive Medical Test Guide
- Why is it done?
- Test Purpose: Measures the concentration of uric acid in a single spot urine sample to assess kidney function, evaluate uric acid metabolism, and detect abnormalities in uric acid excretion.
- Primary Indications: Evaluation of gout or recurrent gout attacks; Assessment of kidney stone formation risk; Monitoring patients with high serum uric acid levels; Evaluation of kidney disease; Assessment of tumor lysis syndrome risk; Investigation of metabolic disorders affecting purine metabolism.
- Timing and Circumstances: Performed during routine urinalysis; When evaluating acute gout flares; Prior to chemotherapy in cancer patients; During assessment of chronic kidney disease; When investigating kidney stone composition; As part of metabolic syndrome evaluation.
- Normal Range
- Reference Values: Adults: 150-750 mg/24 hours (spot urine: 4-9 mg/dL or 0.24-0.54 mmol/L); Values may vary slightly between laboratories based on methodology and reference population.
- Units of Measurement: mg/dL (milligrams per deciliter); mmol/L (millimoles per liter); mg/24h (for 24-hour urine collections).
- Interpretation Basics: Normal: Results within laboratory reference range indicate appropriate uric acid excretion; Low levels: May indicate reduced uric acid excretion or underexcretion; High levels: Suggest increased uric acid excretion or overproduction; Borderline values: Require clinical correlation with serum uric acid levels and patient symptoms.
- Interpretation
- High Urinary Uric Acid: Indicates overproduction or overexcretion of uric acid; Associated with primary gout, secondary gout from malignancy, high purine diet, excessive alcohol consumption, tumor lysis syndrome, or genetic disorders affecting purine metabolism; Increases risk of uric acid kidney stone formation.
- Low Urinary Uric Acid: Suggests underexcretion of uric acid or reduced renal clearance; May indicate kidney disease or dysfunction; Associated with secondary gout, diuretic use, low purine diet, genetic underexcretion disorders, or certain renal tubular conditions; Increases serum uric acid levels despite normal production.
- Normal Range Results: Indicates normal uric acid excretion and metabolism; Does not exclude gout or other uric acid-related disorders when considered with serum uric acid levels; Must be interpreted alongside clinical presentation and serum uric acid concentration.
- Factors Affecting Results: Dietary purine intake (red meat, organ meats, seafood, alcohol); Hydration status and urine concentration; Medications (diuretics, aspirin, allopurinol); Renal function and glomerular filtration rate; Physical activity and metabolic rate; Recent chemotherapy or radiotherapy; Presence of crystalluria or hematuria; Time of day and circadian variations; Acute illness or fever.
- Clinical Significance: Helps differentiate between urate overproducers (high urinary excretion) and urate underexcreters (low urinary excretion); Critical for understanding gout pathophysiology and selecting appropriate treatment; Indicates kidney stone risk and need for preventive measures; Used to assess response to uric acid-lowering therapy; Helps evaluate kidney function and metabolic disorders.
- Associated Organs
- Primary Organ Systems: Urinary system (kidneys, ureters, bladder); Renal glomeruli and tubules (filtration and reabsorption); Liver and muscle tissue (uric acid production); Gastrointestinal tract (purine absorption).
- Diseases and Conditions Associated: Gout and acute gouty arthritis; Chronic kidney disease; Acute kidney injury; Uric acid nephrolithiasis (kidney stones); Tumor lysis syndrome; Lesch-Nyhan syndrome; Polycythemia vera; Myeloproliferative disorders; Psoriasis; Hemolytic anemia; Inflammatory bowel disease; Type 2 diabetes mellitus.
- Potential Complications: Recurrent gout attacks leading to joint damage and chronic arthropathy; Uric acid kidney stone formation causing obstruction and hematuria; Chronic urate nephropathy and progressive renal insufficiency; Acute uric acid nephropathy in tumor lysis syndrome causing acute kidney injury; Tophi formation in chronic gout (deposits in soft tissues); Secondary complications from underlying kidney disease; Cardiovascular complications associated with hyperuricemia.
- Follow-up Tests
- Recommended Follow-up Tests: Serum uric acid level (most important correlate); 24-hour urine uric acid collection (for more accurate excretion assessment); Blood urea nitrogen (BUN) and serum creatinine (assess kidney function); Estimated glomerular filtration rate (eGFR); Complete metabolic panel; Urine pH (acidic urine increases stone risk); Urine culture and urinalysis (detect infections or crystals).
- Further Investigations: Renal ultrasound or CT imaging (evaluate for stones or kidney damage); Dual-energy CT scan (confirm uric acid stone composition); Joint aspiration with crystal analysis (confirm gout diagnosis); Genetic testing (for Lesch-Nyhan syndrome or other inherited disorders); Metabolic workup (for secondary causes of hyperuricemia).
- Monitoring Frequency: Every 3-6 months for gout management and medication adjustment; Annually for chronic kidney disease patients; After acute episodes or therapy changes; Baseline and periodic monitoring during chemotherapy (tumor lysis syndrome prevention); More frequently if abnormal results detected.
- Complementary Tests: Urine specific gravity (assess hydration); Urine phosphate and calcium (evaluate for other stone types); Serum phosphate, calcium, and PTH (metabolic bone disease); Lipid panel (cardiovascular risk assessment); Fasting glucose and HbA1c (diabetes evaluation); Inflammatory markers (CRP, ESR for acute gout).
- Fasting Required?
- Fasting Status: No - Fasting is NOT required for urinary uric acid spot testing.
- Special Instructions: Collect mid-stream urine sample in a clean container (avoid first and last portions of urinary stream); No specific time of day required; Specimen should be analyzed within 24 hours; Maintain normal diet unless specifically instructed otherwise by physician.
- Patient Preparation: Continue normal daily activities and dietary intake; Maintain regular hydration (adequate water intake); Inform healthcare provider of current medications before testing; Note any recent dietary changes affecting purine intake.
- Medications and Supplements: DO NOT discontinue prescribed medications unless instructed by physician; Continue allopurinol, febuxostat, probenecid, and other uric acid-altering medications as prescribed (inform lab of current medications); Report all supplements and herbal preparations; Diuretics and aspirin may affect results - notify provider if taking these medications.
How our test process works!

