Male Hormone Package

Hormone/ Element

5 parameters

Report in 24Hrs

At Home

No Fasting Required

Details

Hormone Profile Check for Males

₹1,499₹2,499

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Parameters

List of Tests
- Testosterone
- Sex Hormone Binding Globulin (SHBG)
- FSH, LH, Prolactin

Male Hormone Package

Why is it done?
- Comprehensive evaluation of male reproductive and endocrine function by measuring key hormones that regulate sexual development, fertility, and secondary sexual characteristics
- Testosterone assessment: Evaluates total testosterone levels to determine if hypogonadism (low testosterone) or hypergonadism exists, affecting sexual function, energy levels, and muscle mass
- SHBG measurement: Determines the binding capacity of hormones and helps calculate free and bioavailable testosterone to assess hormonal bioavailability
- FSH/LH evaluation: Assesses pituitary function and hypothalamic-pituitary-gonadal (HPG) axis integrity for fertility assessment and reproductive hormone regulation
- Prolactin assessment: Evaluates for hyperprolactinemia which can suppress gonadotropin release and cause erectile dysfunction, gynecomastia, or infertility
- Clinical indications: Erectile dysfunction, low libido, infertility, gynecomastia, muscle wasting, decreased energy, mood disturbances, or suspected pituitary disorders
- Diagnostic confirmation: Helps diagnose primary hypogonadism (testicular failure), secondary hypogonadism (pituitary/hypothalamic dysfunction), androgen insensitivity, and hyperprolactinemia
- Monitoring therapy: Tracks testosterone replacement therapy efficacy and evaluates response to treatment for hormonal disorders
- Synergistic analysis: Individual tests work together to identify the specific level of hormonal dysfunction (hypothalamic, pituitary, or testicular) through pattern recognition
Normal Range
- Testosterone (Total): 300-1000 ng/dL (10.4-34.7 nmol/L) for adult males; values show diurnal variation with peaks in early morning hours
- Testosterone (Free): 9.3-26.5 pg/mL (32-92 pmol/L) for adult males; represents biologically active testosterone not bound to proteins
- Sex Hormone Binding Globulin (SHBG): 24-122 nmol/L (10-50 ng/mL) for adult males; variations occur with age, liver function, and metabolic conditions
- Follicle-Stimulating Hormone (FSH): 1.7-8.6 mIU/mL for adult males; slight variations exist between laboratories and testing methodology
- Luteinizing Hormone (LH): 1.7-8.6 mIU/mL for adult males; levels are relatively stable but show pulsatile secretion patterns
- Prolactin: 2.64-13.13 ng/mL (0.11-0.55 nmol/L) for adult males; elevated prolactin is clinically significant when >20 ng/mL
- Interpretation: Normal ranges indicate adequate testicular function, appropriate pituitary stimulation, and proper hormone regulation; borderline values warrant clinical correlation
- Low testosterone with high FSH/LH: Suggests primary testicular failure (primary hypogonadism); indicates testicular tissue damage or dysfunction
- Low testosterone with low/normal FSH/LH: Suggests secondary hypogonadism (hypothalamic-pituitary dysfunction); indicates CNS pathology or pituitary insufficiency
- Elevated prolactin: Suppresses GnRH secretion, leading to decreased FSH/LH and secondary hypogonadism; warrants pituitary imaging evaluation
Interpretation
- TESTOSTERONE - LOW (<300 ng/dL): Clinical hypogonadism; causes include primary testicular failure, pituitary insufficiency, hypothyroidism, obesity, or aging; associated with erectile dysfunction, reduced muscle mass, fatigue, and mood disturbances
- TESTOSTERONE - HIGH (>1000 ng/dL): May indicate polycythemia, increased cardiovascular risk, potential exogenous androgen use, adrenal tumors, or Leydig cell tumors; requires investigation for underlying cause
- TESTOSTERONE - BORDERLINE (300-400 ng/dL): Clinical symptoms may be present despite laboratory values; free testosterone measurement and clinical correlation are essential
- SHBG - LOW (<24 nmol/L): Increases free/bioavailable testosterone; associated with metabolic syndrome, insulin resistance, obesity, and type 2 diabetes; may amplify effects of low total testosterone
- SHBG - HIGH (>122 nmol/L): Decreases free/bioavailable testosterone; associated with hyperthyroidism, cirrhosis, HIV infection, excessive exercise, and aging; may result in functional hypogonadism despite normal total testosterone
- FSH - LOW (<1.7 mIU/mL): Indicates pituitary hypogonadism or secondary gonadal failure; suggests hypothalamic-pituitary dysfunction or suppression from exogenous androgens
- FSH - HIGH (>8.6 mIU/mL): Indicates primary testicular failure; testes are unresponsive to pituitary stimulation, causing compensatory FSH elevation to attempt spermatogenesis
- LH - LOW (<1.7 mIU/mL): Indicates secondary hypogonadism from pituitary/hypothalamic insufficiency; suggests CNS pathology affecting GnRH secretion or pituitary responsiveness
- LH - HIGH (>8.6 mIU/mL): Indicates primary testicular dysfunction; elevated LH attempts to stimulate testosterone production but testes fail to respond adequately
- PROLACTIN - MILDLY ELEVATED (13.13-20 ng/mL): May represent physiologic stress response; requires repeat testing to confirm persistent elevation before extensive workup
- PROLACTIN - SIGNIFICANTLY ELEVATED (>20 ng/mL): Suggests prolactinoma or other pituitary pathology; suppresses GnRH, causing secondary hypogonadism with erectile dysfunction and infertility
- FSH/LH PATTERN ANALYSIS: Low testosterone with elevated FSH/LH indicates testicular primary failure; low testosterone with low FSH/LH indicates pituitary/hypothalamic dysfunction requiring different treatment approaches
- FACTORS AFFECTING RESULTS: Circadian rhythm (testosterone peaks 6-8 AM), stress, sleep deprivation, medications (opioids, glucocorticoids), obesity, liver disease, and recent illness can alter hormone levels
Associated Organs
- TESTES (Primary Target for Testosterone): Produce testosterone via Leydig cells and regulate spermatogenesis through FSH action; abnormal results indicate testicular failure, atrophy, orchitis, trauma, or genetic disorders affecting testosterone synthesis
- PITUITARY GLAND: Produces FSH and LH (gonadotropins) that stimulate testicular function; also produces prolactin; dysfunction causes secondary hypogonadism or hyperprolactinemia
- HYPOTHALAMUS: Secretes GnRH (gonadotropin-releasing hormone) controlling pituitary FSH/LH release; damage or dysfunction results in secondary hypogonadism with low gonadotropins
- LIVER: Produces SHBG and metabolizes hormones; liver disease elevates SHBG and alters testosterone metabolism; cirrhosis causes secondary hypogonadism
- ADRENAL GLANDS: Produce DHEA-S and other androgens contributing to total androgens; adrenal insufficiency may reduce overall androgen production
- THYROID GLAND: Affects metabolism and SHBG synthesis; hypothyroidism lowers SHBG and may cause hypogonadism; hyperthyroidism elevates SHBG reducing free testosterone
- PENIS AND ERECTILE TISSUE: Dependent on testosterone and free testosterone for erectile function and sexual performance; low testosterone causes erectile dysfunction and reduced sexual desire
- SKELETAL MUSCLE: Testosterone drives anabolic effects and protein synthesis; hypogonadism causes muscle loss, weakness, and decreased exercise tolerance
- BONE: Testosterone maintains bone mineral density; hypogonadism accelerates bone loss and increases fracture risk, particularly affecting hip and vertebral bodies
- BRAIN AND CNS: Testosterone affects mood, cognition, and sexual behavior; low levels contribute to depression, cognitive decline, and reduced libido
- CARDIOVASCULAR SYSTEM: Testosterone has complex effects on vascular function; hypogonadism increases cardiovascular risk; excessive testosterone elevates hematocrit and thrombotic risk
- PROSTATE: Testosterone-dependent organ; hypogonadism may reduce prostate size but doesn't eliminate prostate disease risk; hyperandrogenism slightly increases prostate cancer risk
- BREAST TISSUE: Elevated prolactin may cause gynecomastia through increased aromatase activity; low testosterone/high estradiol ratio also contributes to breast enlargement
Follow-up Tests
- FREE TESTOSTERONE (calculated or equilibrium dialysis): Essential follow-up when total testosterone is borderline or normal but clinical symptoms suggest hypogonadism; determines bioavailable hormone
- BIOAVAILABLE TESTOSTERONE: Measures free plus albumin-bound testosterone; more accurate representation of biologically active hormone than total testosterone alone
- REPEAT TESTOSTERONE TESTING: Obtain second morning specimen (ideally 2-4 weeks apart) if initial result is abnormal; confirms diagnosis as single low value may not establish hypogonadism due to circadian variation
- ESTRADIOL: Measure if testosterone is low or high; elevated estradiol with low testosterone suggests gynecomastia risk; high estradiol with high testosterone indicates aromatase overactivity or potential AAS use
- THYROID FUNCTION TESTS (TSH, Free T4): Follow-up if SHBG or prolactin abnormalities present; hypothyroidism causes secondary hypogonadism and elevated SHBG
- LIVER FUNCTION TESTS: Follow-up if SHBG significantly elevated or low; cirrhosis and chronic liver disease affect SHBG production and hormone metabolism
- PROLACTIN - REPEAT TESTING: If elevated, repeat after 30-minute rest in recumbent position; stress and sampling technique elevate prolactin; confirm persistent elevation before further workup
- PITUITARY MRI: Indicated if prolactin >25 ng/mL or secondary hypogonadism (low FSH/LH with low testosterone); evaluates for prolactinoma, pituitary adenomas, or sellar masses
- SEMEN ANALYSIS: Recommended for infertile males with abnormal FSH/LH or testosterone levels; directly assesses spermatogenesis and ejaculate quality
- TESTICULAR ULTRASOUND: Consider if primary hypogonadism with very elevated FSH/LH; evaluates for testicular pathology, atrophy, masses, or varicoceles
- FASTING GLUCOSE AND LIPID PANEL: Essential if SHBG low or testosterone low; metabolic syndrome and insulin resistance commonly coexist with hypogonadism
- COMPREHENSIVE METABOLIC PANEL: Assess renal and hepatic function; important baseline before testosterone therapy and affects SHBG levels
- COMPLETE BLOOD COUNT: Baseline before therapy; elevated hematocrit from testosterone excess increases thrombotic risk
- PSA (Prostate Specific Antigen): Baseline before testosterone therapy for men >40 years or with prostate cancer risk factors; monitor during treatment
- MONITORING ON TESTOSTERONE THERAPY: Repeat hormone panel 6-12 weeks after initiating therapy; adjust frequency based on clinical response and side effects
- GENETIC TESTING: Consider if severe hypogonadism in young male without obvious etiology; may reveal Klinefelter syndrome, Y-chromosome microdeletions, or gene mutations
Fasting Required?
- Fasting Status: NOT REQUIRED for hormone testing in this package; testosterone, SHBG, FSH, LH, and prolactin levels are not significantly affected by fasting state
- TIMING RECOMMENDATION: Collect specimen between 6:00 AM and 10:00 AM when testosterone peaks; draw early morning sample for most accurate total testosterone assessment due to circadian rhythm
- PATIENT PREPARATION: Avoid excessive stress 30 minutes before blood draw; stress elevates cortisol and can affect hormone levels; rest in sitting position for 5 minutes before phlebotomy
- MEDICATIONS TO AVOID: Consult physician about discontinuing testosterone, anabolic steroids, or other androgens 6-12 weeks before testing for baseline assessment; affects testosterone measurements
- MEDICATIONS AFFECTING RESULTS: Opioid medications suppress FSH/LH; glucocorticoids suppress gonadotropins; some anticonvulsants induce SHBG metabolism; 5-alpha reductase inhibitors lower free testosterone
- MEDICATIONS THAT ELEVATE PROLACTIN: Dopamine antagonists (antipsychotics, metoclopramide, domperidone), SSRIs, tricyclic antidepressants, and opioids; report all current medications to phlebotomist
- LIFESTYLE FACTORS: Limit strenuous exercise 24 hours before testing; intense exercise transiently reduces testosterone; maintain normal sleep-wake schedule for 3 days prior to testing
- ALCOHOL CONSUMPTION: Avoid alcohol 24 hours before testing; acute alcohol use affects hormone metabolism and can suppress testosterone levels
- SEXUAL ACTIVITY: Abstain from ejaculation 24 hours before testing; sexual activity and ejaculation can temporarily alter hormone levels
- SLEEP: Ensure adequate sleep (7-9 hours) for 3 nights before testing; sleep deprivation significantly lowers testosterone and affects gonadotropin levels
- ILLNESS: Delay testing if acutely ill; fever, infection, and acute illness suppress testosterone and elevate prolactin; retest 2-4 weeks after recovery
- TEMPERATURE EXPOSURE: Avoid hot baths or saunas 24 hours before testing; heat exposure temporarily affects testicular hormone production
- SPECIMEN HANDLING: Blood drawn into SST (serum separator tube) or red-top tube; separate serum within 2 hours; freeze if delayed processing required
- REPORTING DAY: Most laboratories return results within 24-48 hours; some specialized hormone panels take 3-5 business days for completion

How our test process works!